અમિત પંડ્યા
ગુજરાત હાઇકોર્ટની ટકોરને પણ અમદાવાદ મ્યુનિસિપલ કોર્પોરેશનના એસ્ટેટ ખાતું ઘોરીને પી ગયું તેવું લાગે છે.
અમદાવાદ પૂર્વમાં ઝડપથી વિકસિત વસ્ત્રાલ વિસ્તારમાં યોગ્ય પ્લાન પાસ કરાવી યેનકેન પ્રકારે BU પરમિશન મેળવી લેવાય છે ત્યારબાદ વિસ્તારમાં આવેલ મોટા ભાગના શોપિંગ કોમ્પલેક્ષમાં એસ્ટેટ ખાતાની મીલીભગતથી ગેરકાયદેસર દબાણનો રાફડો ફાટયો છે.
વસ્ત્રાલ વિસ્તારમાં આવેલ મોટા ભાગના શોપિંગ મોલ તથા રહેણાક સોસાયટી એસ્ટેટ ખાતાની રહેમ નજર હેઠળ દબાણો થઈ રહ્યા છે. શોપિંગ મોલ તથા મોટાભાગમાં રહેણાક ફ્લેટની બહારની દુકાનોમાં બહારની બાજુ વિવિધ સ્ટોલને મંજૂરી આપી મોસમોટા ભાડા ઉઘરાવાય રહ્યા હોય તેમ લાગી રહ્યું છે. મોલ ની બહારના ભાગમાં સ્ટોલ કોઈની રહેમ નજર હેઠળ બે રોકટોક ચાલે છે ઉપરાંત વસ્ત્રાલ રિંગ રોડ પર આવેલ વેદ આર્કેદ મોલની બહાર અનેક પ્રકારની ખાણીપીણીની લારી ગલ્લા વાળા તરફથી પણ મોટા પ્રમાણમાં દબાણ થઈ ગયેલ છે. જે સાંજના 6 વાગ્યા બાદ મોટા પ્રમાણમાં દબાણ કરી રહ્યા છે જેના કારણે સર્વિસ રોડ પર ટ્રાફિક જામ થાય છે અને નાના મોટા અકસ્માત થતાં હોય છે. ઉપરાંત આ વિસ્તારમાં અનેક આવા શોપિંગ સેન્ટરની બહાર વિવિધ લારી કે, સ્ટોલ ઊભા થઈ જવાના કારણે લોકો રોડ પર પોતાના વાહનો પાર્ક કરવા મજબૂર બન્યા છે જેના કારણે ટ્રાફિક પોલીસ ક્રેન મારફતે વાહનો ટ્રોય કરે છે પરંતુ ત્યાં ટ્રાફિકને અડચણ રૂપ ખાણીપીણીના લારિ ગલ્લાને કઈ નથી કહેવામાં આવતું.
ઉલ્લેખનીય વાત એ છે કે, એસ્ટેટ ખાતાની દબાણની ગાડી પહોંચે એ પહેલાં તો લારી વાળા પાસે પહેલેથી સમાચાર આવી જાય છે જેથી કરી તેઓ પોતાની લારી જેતે જગ્યા પર ખસેડી લે છે અને દબાણની ગાડી આવી અહીં દબાણ નથી તેમ કહી ચાલી જાય છે અને જેવી દબાણની ગાડી ચાલી જાય કે, તુરંત લારીઓનું દબાણ ફરી પાછું થઈ જાય છે અને પરિસ્થિતિ જેમની તેમ થઈ જાય છે. આવું ખાલી મોલની આસપાસ નથી પરંતુ સમગ્ર વિસ્તારની આવી જ પરિસ્થિતિ છે મોટાભાગના શોપિંગ કોમલેકસમાં દુકાનદારો વિવિધ પ્રકારના લારીગલ્લા મૂકી ભાડાની વસુલાત કરી રહ્યા છે તેમના દ્વારા થયેલ પાર્કિંગ એરિયાના દબાણના કારણે આવનાર ગ્રાહકો રોડ પર વાહન મૂકવા મજબૂર બને છે. ઉપરાંત કેટલીક રોડ પર આવેલ ડુપ્લેકસ સોસાયટીમા રહેણાકના બદલે શેડ બનાવી દુકાનો તૈયાર કરવામાં આવી છે ત્યાં બેરોકટોક ધંધાકીય કાર્ય કરવામાં આવી રહ્યું છે.
સોસાયટીના લોકો દ્વારા આ અંગેની લેખિતમાં વારંવાર રજૂઆત કરવામાં આવી છતાં પણ એસ્ટેટ ખાતા દ્વારા દબાણ દૂર કરવા માટે કોઈ પણ પ્રકારની કાર્યવાહી હાથ ધરવામાં નથી આવી રહી. જો કાર્યવાહી કરવા દબાણની ગાડી પહોંચે તે પહેલાં તો લારી ધારકને પહેલાથી જ સમાચાર આપી દેવામાં આવે છે જેથી કરીને તે સમયે તેઓ પોતાની લારી ત્યાંથી ખસેડી લે છે. શું લારી વાળાઓ દ્વારા નિયમિત રીતે હપ્તા આપવામાં આવે છે ? તેવું લાગી રહ્યું છે.
આ હપ્તા રાજ બંધ કરી ગુજરાત હાઇકોર્ટના દિશાનિર્દેશ મુજબ અમદાવાદ મ્યુનિસિપલ કોર્પોરેશનનું પૂર્વ ઝોન એસ્ટેટ ખાતું દ્વારા કોઈ નક્કર કાર્યવાહી થાય.
વસ્ત્રાલ વિસ્તારના લોકોની માંગણી છે કે, આવા દબાણો હટાવવા માટે અધિકારીઓ દ્વારા સાંજના 6 વાગ્યા પછી કાર્યવાહી કરવામાં આવે અને નક્કર પગલાં લેવામાં આવે અને ફરીથી આ જગ્યા પર લારીનું દબાણ ફરીથી ન થાય તેનું આયોજન કરી વારંવાર દબાણ હટાવાની કાર્યવાહી થાય.
2 COMMENTS
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Corticosteroid Adverse Effects
The use of corticosteroids is associated with a wide
range of adverse effects, which can occur due to their potent glucocorticoid activity.
The following are key points to consider:
Adrenal Suppression
Long-term or high-dose corticosteroid therapy
may suppress the hypothalamic-pituitary-adrenal (HPA) axis,
leading to reduced production of endogenous cortisol.
This can result in:
Cortisol deficiency (e.g., adrenal insufficiency)
Adrenal atrophy
Thromboembolism and Vascular Disruption
Corticosteroids can contribute to hypercoagulation, increasing the risk of:
Deep vein thrombosis (DVT)
Pulmonary embolism
Atherosclerosis
Metabolic Disturbances
Changes in metabolism include:
Lipodystrophy
Fatty liver
Hyperglycemia and insulin resistance
Musculoskeletal Effects
Corticosteroids can lead to:
Osteoporosis (due to reduced bone density)
Amygdala enlargement
Proximal muscle weakness
Dermatological Adverse Effects
The skin may experience:
Acneiform eruptions
Facial discoloration
Hypertrichosis (excess hair growth)
Others
Additional potential effects include:
Immunosuppression
Eye changes (e.g., posterior subcapsular cataracts)
Neuropathy
Key Considerations
Risk factors for corticosteroid adverse effects include:
High doses or prolonged therapy
Individual susceptibility
Concurrent use of other medications (e.g., warfarin, NSAIDs)
It is essential to weigh the benefits and risks of corticosteroid therapy and consider alternative treatments when possible.
Introduction
Corticosteroids are a class of drugs commonly used in the treatment of various inflammatory conditions, immune disorders, and other medical conditions.
While these medications can be highly effective, they are
also associated with a spectrum of potential adverse effects.
Understanding these effects is critical for healthcare providers to safely and effectively manage patient
care.
Account
Corticosteroids are derived from cholesterol and function as potent anti-inflammatory agents through their ability to suppress
the immune response and modulate the activity of cells involved in inflammation.
Their widespread use necessitates a thorough understanding of both their therapeutic benefits and potential side
effects.
Bookshelf
The NCBI Bookshelf StatPearls provides a comprehensive resource for healthcare professionals to access information on drug dosing, indications, adverse effects, and other clinical considerations.
This tool is an invaluable resource for staying updated on the latest guidelines and evidence-based practices in therapeutics.
StatPearls
The NCBI Bookshelf StatPearls platform is a widely
used clinical decision-making tool that offers detailed information on various
drugs, including corticosteroids. It allows users to quickly access key
details such as indications, dosage guidelines, adverse effects,
and patient monitoring strategies.
Corticosteroid Adverse Effects
Adverse effects associated with corticosteroid use can range from mild to severe
and include a variety of clinical presentations.
Common side effects include:
– Glucocorticoid Resistance: A rare condition where the body’s cells become unresponsive to the therapeutic effects of corticosteroids, often leading to treatment failure.
– Adrenal Suppression: Long-term use can suppress the hypothalamic-pituitary-adrenal (HPA) axis, potentially causing Addisonian crisis in susceptible individuals.
– Thromboembolic Events: An increased risk of blood clots,
which can lead to serious complications such as deep
vein thrombosis and pulmonary embolism.
– Moon Face Syndrome: A rare condition characterized by a
distortion of facial features due to the redistribution of fat in the face.
Authors
The authors of this article are healthcare professionals with expertise
in pharmacology, internal medicine, and clinical practice.
Their contributions ensure that the information presented is evidence-based,
accurate, and relevant to clinical practice.
Affiliations
The affiliations of the authors reflect their institutional roles and areas of research expertise.
This information provides readers with context about the qualifications and experience of those contributing
to the article.
Continuing Education Activity
This activity serves as a continuing education opportunity for
healthcare professionals to enhance their knowledge and skills in the use of corticosteroids and
the management of associated adverse effects.
Indications
Corticosteroids are used in the treatment of a
wide range of conditions, including inflammatory bowel disease (IBD), autoimmune diseases such as rheumatoid
arthritis, and allergic disorders like asthma and chronic obstructive pulmonary
disease (COPD). Their efficacy in these conditions makes them a
cornerstone in modern therapeutic medicine.
Mechanism of Action
Corticosteroids exert their therapeutic effects by binding to glucocorticoid receptors located on the surface of target cells.
This interaction leads to the suppression of pro-inflammatory genes, thereby reducing the severity of inflammatory reactions and immune responses.
Administration
Corticosteroids are typically administered orally or via inhalation, depending on the specific indication. Intravenous
and intramuscular routes are also used in certain cases.
Proper dosing and route selection are critical to achieving therapeutic
benefits while minimizing adverse effects.
Adverse Effects
The risk of corticosteroid-related adverse effects is dose-dependent and increases
with the duration of treatment. Monitoring for common and serious
side effects is essential.
Contraindications
Corticosteroids are contraindicated in individuals
with a history of hypersensitivity to the drug, active or inactive tuberculosis (due to the risk of reactivation), and certain genetic conditions that predispose to adrenal insufficiency.
Monitoring
Close monitoring of patients receiving corticosteroid therapy is necessary to assess therapeutic response and
detect adverse effects early. Regular laboratory tests, including serum cortisol levels and blood counts, can help guide adjustments in treatment.
Toxicity
Corticosteroid toxicity refers to the harmful effects that occur
when the body is exposed to excessive or prolonged levels of these hormones.
This toxicity can manifest as a variety
of clinical symptoms, including muscle wasting, bone demineralization, and
the development of Cushings syndrome.
Enhancing Healthcare Team Outcomes
Effective communication and collaboration among healthcare team members are essential for optimizing
patient outcomes in the context of corticosteroid therapy.
Regularly reviewing treatment plans and monitoring for adverse effects can help ensure that patients receive safe, effective care.
Review Questions
To test your understanding of this article,
consider answering the following questions:
1. Which condition is associated with an increased risk of thromboembolic events in corticosteroid
users?
a) Glucocorticoid resistance
b) Adrenal suppression
c) Thromboembolic events
d) Moon face syndrome
2. What is the primary mechanism of action for corticosteroids in inflammatory conditions?
a) Inhibiting cytokine production
b) Blocking transcription factors involved in inflammation
c) Suppressing immune responses
d) Allowing cells to heal more quickly
3. Which route of administration is commonly used for corticosteroid therapy?
a) Intravenous
b) Subcutaneous
c) Oral
d) Inhaled
References
The information in this article is based on the NCBI Bookshelf StatPearls resource.
For further reading and detailed guidelines, please refer
to the following reference:
– NCBI Bookshelf – StatPearls Internet. U.S.
National Library of Medicine.
Views
The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the institutions or organizations with which they are affiliated.
In This Page
– Account: Overview of corticosteroid pharmacology and clinical use.
– Bookshelf: Access to detailed drug information via NCBI StatPearls.
– StatPearls: A clinical decision-making tool for healthcare providers.
Bulk Download
For bulk downloads or further access to the content, please refer to the related information section below.
Related Information
– Similar articles in PubMed: Search for “Corticosteroid Adverse Effects” to find related articles and research studies.
– Recent Activity: Stay updated with the latest advancements
in corticosteroid research and clinical practice.
my page steroid Research – http://www.tricflash.Com
–
Today, Anavar remains to be broadly used in the
health and bodybuilding communities. Nevertheless,
its use is highly regulated and managed as a outcome of its potential for abuse and harmful side effects.
Although most customers have a tendency to use it as a compound for the upkeep of muscle mass during
a hypocaloric fat loss cycle, its use actually extends far
past that. As A End Result Of of Anavar’s energy being
that of three occasions Testosterone, it is very properly potential for Anavar to be effectively utilized
as a mass gaining (or even a bulking) agent. In comparison to compounds
sometimes used as bulking brokers, such as Dianabol, Anavar holds the advantage of zero
estrogenic activity. Over the early years of its existence, Anavar has been used exclusively as a chopping agent during
times of fats loss, however as of latest it has begun to
see its use increase to that of lean mass gaining. As information will increase and ease of entry to info expands, more are studying that compounds similar
to Anavar are literally far more versatile than as
soon as thought.
This makes it an ideal steroid for many who need to keep away from long-term exposure to anabolic steroids.
When it involves the appearance of Anavar, it’s
obtainable in pill kind and is often white or off-white in color.
Nevertheless, you will want to observe that the color of Anavar tablets can vary
depending on the producer and the dosage. The answer is that it
is decided by the manufacturer and the precise formulation of the drug.
Nevertheless, generally, Anavar tablets are typically white
or off-white in color and could additionally be scored for simple splitting.
It is essential to notice that the looks of Anavar can vary broadly relying on where it’s
manufactured and what different elements are included in the pill.
Lastly, Oxandrolone can support fat loss, a side crucial to bodybuilders, especially those making ready for competitions.
Oxandrolone is thought for promoting lipolysis, the process by which your body burns and makes use of fat for vitality.
Anavar drugs are recognized in the bodybuilding community as a game-changer.
Not some magical substance, however a well-researched, widely-used anabolic
steroid promising amplified outcomes. Typically encapsulated in gentle gel tablets, Anavar pills have a particular id, owing to their impressive performance and notable
impacts on the human physique. Excretion rates depend on renal operate, hydration status, and urinary pH.
Impaired kidney perform can extend drug retention, growing systemic publicity.
Availability and ease of access, authorized conditions, and pricing of Oxandrolone will differ
across completely different parts of the world.
Having a PCT plan able to go for the end of your Anavar cycle is a straightforward way of avoiding low testosterone.
Masteron is thought to be a better mood enhancer than Anavar,
but this effect can be very individual-dependent. Most
Masteron users may also see the next increase to the libido
than is usually experienced with Anavar. On the downside for Masteron, it dries out
the joints and may trigger joint ache, whereas Anavar can be joint supportive to a level.
Anavar has a benefit here and may also have a
more optimistic effect on your tendons and joints.
Anavar was designed for short-term use, and medical assets,
corresponding to WebMD, point out that abusing this
drug with high doses and prolonged intake may also trigger
cardiovascular points [8]. Anavar will predominantly impact
the expansion of human tissue like muscle tissue and
bones, based on the MedlinePlus [4]. Anavar was as soon as
used to advertise growth in youngsters, however now growth hormones are more commonly used for this
purpose. Anavar can even have an effect on temper in women, resulting in elevated aggression, irritability, or anxiety.
These mood changes could be tough to handle and
will impression personal and skilled relationships.
It is quite delicate actually most will find liver enzyme values to solely enhance at a
minimal price with accountable supplementation.
Anavar, also identified as “Var” or “A-var” when discussing it’s use
as a sports activities performance enhancer.
This article covers the legal anavar supplement, as properly as the earlier a-var which
contained oxandrolone. Skilled users with lower body weight/levels of musculature ought to reduce the upper-end doses by round 10mg.
SARMs are typically thought of safer than conventional
steroids, as they aim specific tissues and sometimes have
fewer unwanted effects.
Speak to a healthcare skilled earlier than taking any supplements to make certain that they’re
secure and suitable for your wants. Keep In Mind that Anavar just isn’t a
magic pill, and it is essential to keep up a wholesome life-style and train often to achieve your health goals.
Then, when the pill is within the “safer” part of the intestine (upper
intestine), the nutrients start to be released into the system and proceed to be launched steadily over a two to eight-hour interval.
With this kind of controlled-release delivery, testosterone levels could be elevated for up to eight
hours by a single dose of Anavar®. Current tablets or capsules bioavailability of Androstenolone and Androsterone is
approximately a mere 1.5%-4%.
Anavar is a relatively mild steroid, in comparability with other AAS such as
trenbolone or anadrol. Nonetheless, anavar’s a banned substance and is unlawful to buy in many countries
– with no prescription (including US and UK).
#2 Expertise – if you’ve by no means been to the fitness center and are very inexperienced then it’s not needed to leap to performance
enhancing drugs. Hire a private trainer and tidy up your nutrition and you’ll notice improvements.
If a beginner takes Anavar although they could notice some improvements they doubtless wont see the same enhancements as someone who’s been training for
5+ years and has hundreds of hours lifting experience. One issue
some athletes/bodybuilders can expertise when in a calorie
deficit is muscle loss.
Testosterone ranges sometimes recover one to 4 months after Anavar cycle cessation. An efficient PCT protocol
can speed up the recovery of endogenous testosterone.
Anavar has beforehand been labeled efficient and protected by researchers.
We know that when utilized in a clinical setting with low to average doses, Anavar does not typically produce dangerous unwanted
effects.
When anabolic steroids are taken with meals, absorption is inhibited.
This is because of them being fat-soluble compounds, thus inflicting the steroid to dissolve when taken with dietary fat.
Subsequently, Anavar and other anabolic steroids must be taken on an empty abdomen for
optimal results. When Anavar (oxandrolone) was first produced,
it was legal to purchase for bodybuilding functions.
Doctors would prescribe it to folks wanting larger muscular tissues, more strength, or to burn excess
fat. Testicular atrophy is a standard signal of decreased testosterone levels
and impaired spermatogenesis.
We can offer you the identical kind of testosterone your physique produces.
Of course, there might be still the potential for unwanted
effects, however because it is bio-identical, your body is extra receptive to it, and you
may proceed remedy safely for many years. I am a muscular guy with much consideration and recognition for my physique.
I started with little or no and at all times
put 110% into the fitness center to get to the place I
am now.
Anadrole re-creates the consequences of Oxymethalone (known as
Anadrol, some of the highly effective anabolic steroids
in existence) but without the unwanted facet effects. Step on the
human growth hormone fuel, fire up muscle development and burn through
fats stores. One such alternative is Anvarol, which is a authorized, safe, and pure model of
Anavar. It is created to imitate the results of Anavar without causing any of the harmful side effects.
Anvarol is created from natural components and is suitable for each men and women. Whereas Anvarol
is a superb different to Anavar, it’s essential to notice that
it’s not a magic tablet. It’s necessary to
follow a proper exercise routine and diet to see outcomes.
References:
complications from long term steroid use
(careers.jabenefits.com)